Hello,
Yes this is possible but will require some editing to the code. If you open up the mod_s5_slideshowadvance.php file and look at about line 328 you'll notice:
<div class="s5_magglasstop_sa">
<a href="<?php echo $sa_picture1_1 ?>" rel="lytebox[gallery]" title="<?php echo $sa_picture1h1 ?> - Image 1">
<span class="s5_magglass_sa"></span>
<img src="<?php echo $sa_picture1_1 ?>" height="75" width="106" class="s5_thumbnails_sa2" alt="" />
</a>
</div>
The second line is the link as you can see. So you can change this to whatever you want, for example:
Original:
<a href="<?php echo $sa_picture1_1 ?>" rel="lytebox[gallery]" title="<?php echo $sa_picture1h1 ?> - Image 1">
Changed to something like:
<a href="http://www.yoursitehere.com">
Now you will notice there are 10 similar lines or chunks of code and each one includes 4 links for the additional images. You can identify each slide by these chunks. Look at line 318 and you'll notice:
<?php if ($sa_picture1 != "") { ?>
This is for the first slide, the second is:
<?php if ($sa_picture2 != "") { ?> and so on.
Hope this helps.
Regards,